Direct Design came to us to get a Content Management System integrated into their existing Agfest design. It was a really nice clean design, with well managed menus - pages with sub pages via drop down menu on the left, slideshow on the right, and then the main content in the middle.
We took the existing design and reworked it into valid XHTML/CSS, implemented CSS drop-down menus and a dynamic flash slideshow.
The Content Management System then seamlessly plugs in the bits and pieces where they belong - the page tree for the menu is managed, the content is managed, as are all files and slideshows.
You can see below how the admin area manages the page editing, file library and image library and how that maps automatically into the public page.